Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration?
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چکیده
منابع مشابه
Small-molecule-induced clustering of heparan sulfate promotes cell adhesion.
Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells by binding selectively to heparan sulfate on the cell surface. The present study combined chemical, physicochemical, and cell biological experiments, using adhesamine and its analogues, to examine the mechanism by which this dumbbell-shaped, non-peptidic molecule induces physiologically relevant ce...
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Previous work suggests that cell surface heparan sulfate acts as a receptor for the Apicomplexan parasite Toxoplasma gondii. Using Chinese hamster ovary cell mutants defective in heparan sulfate biosynthesis, we show that heparan sulfate is necessary and sufficient for infectivity. Further, we demonstrate that the parasite requires N sulfation of heparan sulfate initiated by N-deacetylase/N-sul...
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ance to peanuts. J. Clin. Invest. 111:1065–1072. doi:10.1172/JCI200316142. 7. Cohen, S.B., Webb, L.M., and Feldmann, M. 1996. The method of deriving human T-cell clones alters the proportion of IL-10-producing cells. Immunology. 87:343–347. 8. Demeure, C.E., et al. 1995. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral ...
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Graft-versus-host disease (GVHD) remains the most common cause of nonrelapse-related morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although T-cell depletion and intensive immunosuppression are effective in the control of GVHD, they are often associated with higher rates of infection and tumor recurrence. In this study, we showed that heparan sulfa...
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The isolation, purification and structural characterization of human liver heparan sulfate are described. 1H-NMR spectroscopy demonstrates the purity of this glycosaminoglycan (GAG) and two-dimensional 1H-NMR confirmed that it was heparan sulfate. Enzymatic depolymerization of the isolated heparan sulfate, followed by gradient polyacrylamide gel, confirmed its heparin lyase sensitivity. The con...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2017
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.29381